Abstract Detail

Poster Session

Li, Tracy [1], Nelson, Kate [2], Quave, Cassandra [3].

Anti-acne activity of Schinus terebinthifolia, a medicinal plant traditionally used to treat skin and soft tissue infections.

Schinus terebinthifolia Raddi, Anacardiaceae, has a long history of use in traditional medicine in South America.  All parts of the plant are commonly used as an astringent, antibacterial, antiviral, and wound healing agent.  Due to its relevance to skin infections, it was selected for investigation against Propionibacterium acnes.  
P. acnes is a Gram-positive, anaerobic bacterium that is involved in the pathogenesis of acne, a disease which affects more than 45 million Americans. Through improper use of antibacterial treatments, P. acnes has evolved antibiotic resistance and thus is an important target for drug discovery efforts.  
Extracts of the leaves and fruit were initially screened for growth inhibitory action under anaerobic conditions against P. acnes at 256ug/mL at 37° C for 72 hours. Extracts with >45% inhibition were retested at a range of 4-256 ug/mL by serial dilution. The EtOAc partition of the fruit extract demonstrated the greatest activity with a minimum inhibitory concentration, or MIC50 of 64 ug/mL and MIC90 of 256 ug/mL.  In conclusion, we found that extracts of a traditional medicinal plant for skin infections did exhibit notable bioactivity against P. acnes growth. Future work will focus on further analysis of this fraction in the context of biofilm models and cytotoxicity tests with human keratinocytes.

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1 - Emory University, Atlanta, GA, 30322, USA
2 - Emory University, Dermatology, Atlanta, GA, 30322, USA
3 - Emory University School of Medicine, Dermatology, 615 Michael St., Whitehead 105L, Atlanta, GA, 30322, USA

Propionibacterium acnes
antimicrobial plants
Phytochemical screening.

Presentation Type: Poster
Abstract ID:82
Candidate for Awards:Julia F. Morton Award